Fat on the Brain and how it May be Connected to Alzheimers.

Fat on the Brain and how it May be Connected to Alzheimers.

Our Brain is 60% Fat

The study by Borg and colleagues suggests that a high fat diet could quite literally leave you with ‘fat on the brain’ Which in studies has been connected to Alzheimers.

According to this research, an excess intake of dietary fat translates into increased lipid content of brain tissues, which is likely to have significant (and probably negative) consequences for brain function.

This work builds on previous studies in both animals and humans which have shown that consuming excessive amounts of fat in the diet leads to an increased accumulation of lipid in peripheral tissues which aren’t designed for fat storage, particularly the skeletal muscle and liver, in a process referred to as ectopic fat storage (Frayn, 2001; Kopecky et al. 2002).

Alzheimers

The resulting increase in the fat content of these tissues interferes with their ability to function normally, and is implicated in many of the co-morbidities associated with diet-induced obesity, in particular insulin resistance 

In the skeletal muscle and liver, for example, increases in lipids such as ceramide and diacylglycerol block insulin signalling, leading to reduced glucose uptake in the muscle and impaired suppression of glucose output by the liver, both of which contribute to peripheral hyperglycaemia and ultimately lead to whole body insulin resistance (Kopecky et al. 2002).

Whilst the association between high fat diets and increased fat accumulation is well established and has been looked at in a range of important metabolic tissues, including the pancreas, liver and muscle.

The study by Borg and colleagues is the first to show that this also occurs in the brain.

In this study, mice were fed for 12 weeks on either a low fat diet, which supplied 5% energy from fat, or a micro-nutrient-matched high fat diet, supplying 59% energy from fat.

The hypothalami (a region known to be critical for the regulation of energy balance) of the mice were then collected and examined for signs of lipid accumulation.

These investigations revealed that the levels of several lipids, particularly those known to be involved in insulin resistance, were significantly elevated in the brains of the mice on the high fat diet at the end of the feeding period.

Alzheimers

A breakthrough in Alzheimer’s research reveals that an abnormal build-up of fat droplets in the brain may cause or speed up the disease. The finding promises to open new avenues in the search for a cure or new treatments.

The research, led by the Research Center of the University of Montreal Hospital (CRCHUM) in Canada, is published in the journal Cell Stem Cell.

The researchers note how, for the first time since 1906, when Dr. Alois Alzheimer first described the disease that takes his name, they found accumulations of fat droplets in the brains of patients who died of the disease.

They have also identified the type of fat.

They were astonished to find fat droplets near the stem cells in the brains of mice bred to develop a form of Alzheimer’s disease.

Alzheimers

Significant fat build up in brains of people who died of Alzheimer’s disease

The team went on to compare the brains of nine patients who died from Alzheimer’s disease with the brains of five people who did not die of the disease. They found significantly more fat droplets in the brains of the patients with Alzheimer’s disease.

“We discovered that these fatty acids are produced by the brain, that they build up slowly with normal aging, but that the process is accelerated significantly in the presence of genes that predispose to Alzheimer’s disease.”

The researchers found that the brains of mice predisposed to the disease build up these fatty acid deposits at 2 months, which in human terms would be the early twenties.

“Therefore, we think that the build-up of fatty acids is not a consequence but rather a cause or accelerator of the disease,” Prof. Fernandes says.

Alzheimers

Look how Fat affects our entire body

Body scan of 250 pound woman and 120 pound woman. If this isn’t motivation to live a healthier lifestyle, I don’t know what is!!

Look at the size of the intestines and stomach; how the knee joints are rubbing together; the enlarged heart; and the fat pockets near the brain.

It’s not about being skinny.. It’s about being HEALTHY

At your cellular level.

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